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Diffuse idiopathic skeletal hyperostosis: A review
Fábio A Nascimento1, Luana Antunes Maranha Gatto2, Roberto Oliver Lages3
1Faculty of Medicine, Universidade Federal do Paraná, Brazil.
Surgical Neurology International
|May 21, 2014
Summary
Diffuse idiopathic skeletal hyperostosis (DISH) involves spinal ligament calcification and presents varied symptoms. Its exact prevalence is unknown, but genetic and external factors contribute to its development.
Area of Science:
- Rheumatology
- Orthopedics
- Internal Medicine
Background:
- Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic, noninflammatory condition characterized by entheseal ossification.
- DISH affects spinal ligaments, particularly the anterior longitudinal ligament.
Purpose of the Study:
- To review the etiopathogenesis, epidemiology, clinical features, differential diagnosis, and treatment of DISH.
- To synthesize current literature on DISH management and understanding.
Main Methods:
- Literature review of available scientific publications.
- Synthesis of data on DISH pathogenesis, clinical presentation, and associated conditions.
Main Results:
- The exact prevalence and incidence of DISH are undetermined.
- Multiple genetic and external factors are implicated in DISH pathogenesis.
- Clinical manifestations range from synovitis to airway obstruction, often with comorbidities like obesity, hypertension, and diabetes.
Conclusions:
- DISH is characterized by anterior longitudinal ligament calcification.
- The disease presents with diverse clinical features and is frequently associated with metabolic comorbidities.