Interaction of vanadate and chloride in chicks

Six experiments have been conducted examining the interaction of dietary sodium chloride levels and vanadate toxicity in chicks. Increasing the dietary supplement of NaCl from 0.5 to 2.0% resulted in amelioration of vanadate toxicity, as measured by growth rate. The amelioration was found to reside in the chloride ion. Hepatic, renal, and femur vanadium concentrations were usually reduced at the higher levels of NaCl supplementation, but there was little correlation between these reductions and the reversal of vanadate toxicity.