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Biological activity of some Schiff bases and their metal complexes
R K Parashar1, R C Sharma, G Mohan
1Department of Chemistry, Agra University, India.
Biological Trace Element Research
|January 1, 1989
Abstract:
Schiff bases derived from salicylaldehyde and 2-substituted aniline and their metal chelates with Cu(II), Ni(II), and Co(II) ions were synthesized and screened for the antiinflammatory and antiulcer activity. The compound salicylidene-anthranilic acid (SAA) was found to possess the antiinflammatory and antiulcer activity. The copper complexes showed an increased antiulcer activity. The SAA is perhaps acting by influencing prostaglandin biosynthesis.