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Related Experiment Videos

Ascorbic acid supplementation and copper status in rats.

G J Van den Berg1, J P Van Wouwe, A C Beynen

  • 1Department of Radiochemistry, Interfaculty Reactor Institute, Delft University of Technology, The Netherlands.

Biological Trace Element Research
|January 1, 1989
PubMed
Summary

High dietary ascorbic acid (vitamin C) significantly reduced copper levels in rats by impairing intestinal absorption. This suggests the body compensates by preserving existing copper stores.

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Area of Science:

  • Nutritional biochemistry
  • Mineral metabolism
  • Toxicology

Background:

  • Ascorbic acid (vitamin C) is an essential nutrient with various physiological roles.
  • Copper (Cu) is a vital trace element involved in numerous enzymatic processes.
  • Interactions between ascorbic acid and copper metabolism are not fully understood.

Purpose of the Study:

  • To investigate the impact of high dietary ascorbic acid on copper status in rats.
  • To determine if ascorbic acid affects copper absorption and retention.
  • To elucidate the mechanisms underlying ascorbic acid-copper interactions.

Main Methods:

  • Rats were fed a purified diet with adequate copper (150 mumol/kg) and a high concentration of ascorbic acid (1%, w/w) for 6 weeks.
  • Copper concentrations in muscle and bone were measured.

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  • Whole-body copper content was estimated.
  • Absorption and retention of orally and intraperitoneally administered 64Cu were assessed.

    • Main Results:

    • High ascorbic acid intake significantly reduced copper concentrations in muscle and bone.
    • Estimated whole-body copper content decreased by 20% in rats fed ascorbic acid.
    • Oral 64Cu administration showed increased fecal excretion, indicating reduced intestinal absorption.
    • Intraperitoneal 64Cu administration resulted in decreased whole-body loss, suggesting enhanced retention.

    Conclusions:

    • High dietary ascorbic acid impairs intestinal copper absorption in rats.
    • This impaired absorption appears to trigger compensatory mechanisms for copper conservation.
    • The findings highlight a significant interaction between ascorbic acid and copper metabolism, with implications for nutritional status.