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Getting control of uncontrolled asthma.

Michael E Wechsler1

  • 1National Jewish Health, Denver, Colo.

The American Journal of Medicine
|May 22, 2014
PubMed
Summary

Uncontrolled asthma affects many patients, increasing exacerbations and healthcare costs. New therapeutic options are needed, alongside improved assessment and management strategies for better asthma control.

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Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Pharmacology

Background:

  • A significant patient population experiences uncontrolled asthma despite available treatments.
  • Uncontrolled asthma leads to severe exacerbations, reduced quality of life, and substantial healthcare costs.
  • Accurate diagnosis and continuous monitoring of asthma control are crucial.

Purpose of the Study:

  • To review current global guidelines for asthma control assessment and management.
  • To summarize novel therapeutic agents under development for asthma treatment.
  • To highlight the need for improved strategies for uncontrolled asthma.

Main Methods:

  • Review of current national and international asthma management guidelines.
  • Analysis of validated tools for asthma control assessment (questionnaires, biomarkers, bronchoscopy).
  • Summary of emerging asthma therapies, including anticholinergics and biologics targeting specific inflammatory pathways.

Main Results:

  • Current guidelines recommend self-management programs and educational action plans for patients.
  • Despite numerous therapies, uncontrolled asthma remains a significant clinical challenge.
  • Novel agents targeting chemoattractant receptors and interleukins (IL-5, IL-13, IL-4) show promise.

Conclusions:

  • Effective asthma control requires accurate assessment, patient self-management, and adherence to guidelines.
  • The development of new targeted therapies is essential to address the unmet needs in uncontrolled asthma.
  • A multi-faceted approach combining guideline adherence and novel treatments is needed for improved patient outcomes.
Keywords:
AsthmaAsthma triggersLong-acting anticholinergicsLong-acting β2-agonistsSpirometry

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