Clinical significance of integrin β6 as a tumor recurrence factor in follicular thyroid carcinoma
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Updated: Apr 29, 2026

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Published on: August 23, 2019
Zhuo-nan Zhuang1,2, Zhen-jie Xu3, Qian Zhou4
1Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Shandong, People's Republic of China.
Background:
Overexpression of integrin β6 plays an important role in a variety of malignant tumor invasion and metastasis.
Methods:
The expression levels of integrin β6, matrix metalloproteinase (MMP)-2 and MMP-9 were analyzed by immunohistochemistry with human follicular thyroid carcinomas. Then we investigated their correlation with clinical outcomes parameters, relationship, and the survival time.
Results:
The integrin β6 staining was expressed in cellular membrane and cytoplasm of follicular thyroid carcinoma cells. The MMP-2 and MMP-9 expressions were mainly found in cellular cytoplasm. In correlation with the clinical outcome parameters of 60 patients, there were significant statistical differences of integrin β6, MMP-2, and MMP-9 expression levels in different size of tumor. Integrin β6 and MMP-9 expressions have significant statistical differences in T classifications. MMP-2 and MMP-9 expressions have significant statistical differences in different M classification. Other clinical outcome parameters had no significant statistical differences.
Conclusion:
Integrin β6 expression correlated significantly with MMP-9 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas.
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