Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

34
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
34
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

16.1K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
16.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fatal pediatric collapse with bilateral subdural hematoma and retinal hemorrhage occurring in a public park: a forensic case study.

Journal of forensic and legal medicine·2026
Same author

A critical review of the American Academy of Pediatrics technical report on abusive head trauma.

Forensic science international. Synergy·2025
Same author

Response to Comment on 26 cm Fall Caught on Video Causing Subdural Hemorrhages and Extensive Retinal Hemorrhages in an 8-Month-Old Infant.

Clinical case reports·2025
Same author

Cephalhaematoma in Sweden, a Population-Based Register Study.

Acta paediatrica (Oslo, Norway : 1992)·2025
Same author

Response to Accidental Versus Abusive Head Trauma in Infancy: Is Revival Shaking the Missing Link?

Clinical case reports·2024
Same author

26 cm fall caught on video causing subdural hemorrhages and extensive retinal hemorrhages in an 8-month-old infant.

Clinical case reports·2024
Same journal

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management.

Developmental medicine and child neurology·2026
Same journal

Hammersmith Infant Neurological Examination global scores for predicting neurodevelopmental outcomes after 2 years of age: A systematic review and meta-analysis.

Developmental medicine and child neurology·2026
Same journal

Seizure worsening and sodium channel blockers in HCN1-related epilepsies: A case series.

Developmental medicine and child neurology·2026
Same journal

What is the impact of childhood-onset disability research - and what should it be?

Developmental medicine and child neurology·2026
Same journal

Sleep disturbances in children with cerebral palsy, their siblings, and parents: A qualitative descriptive study.

Developmental medicine and child neurology·2026
Same journal

Reframing early socio-emotional risk in infants at high risk of cerebral palsy beyond motor outcomes.

Developmental medicine and child neurology·2026
See all related articles

Related Experiment Video

Updated: Apr 29, 2026

Functional Calcium Imaging in Developing Cortical Networks
16:33

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

41.3K

Patterns and pathways of calcification in the developing brain.

Emily McCartney1, Waney Squier

  • 1Department of Neuropathology, Oxford University John Radcliffe Hospital, Oxford, UK.

Developmental Medicine and Child Neurology
|May 22, 2014
PubMed
Summary
This summary is machine-generated.

Brain calcification in developing brains occurs through two pathways: dystrophic and vascular. Non-necrotic calcification appears to initiate in pericytes associated with blood vessels, impacting brain development.

More Related Videos

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.8K
Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.6K

Related Experiment Videos

Last Updated: Apr 29, 2026

Functional Calcium Imaging in Developing Cortical Networks
16:33

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

41.3K
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.8K
Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.6K

Area of Science:

  • Neuroscience
  • Pathology
  • Developmental Biology

Background:

  • Brain calcification is a pathological process observed in the developing brain.
  • Understanding the cellular origins and pathways of calcification is crucial for diagnosing and managing associated neurological conditions.

Purpose of the Study:

  • To identify specific cell types involved in brain calcification.
  • To elucidate the distinct pathways through which calcification occurs in the developing brain.

Main Methods:

  • Histopathological examination of 28 autopsied brains (22 weeks gestation to 14 years).
  • Utilized routine stains, calcification stains, and specific markers for endothelium and macrophages.
  • Investigated cases with known genetic mutations (occludin gene) and various diseases.

Main Results:

  • Identified two primary calcification pathways: dystrophic and vascular.
  • Dystrophic calcification linked to cell death in ischemia and infections.
  • Vascular calcification initiated in protein globules outside small vessel endothelium, with one form affecting arterial adventitia, sparing endothelium.

Conclusions:

  • Non-necrotic brain calcification originates in perivascular cells, potentially pericytes.
  • Vascular calcification leads to vessel rigidity, reduced compliance, and altered permeability.
  • These vascular changes may contribute to cortical malformations, atrophy, and gliosis in the developing brain.