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Related Experiment Videos

Selenium in total parenteral nutrition.

H B von Stockhausen1

  • 1Universitaets-Kinderklinik, University of Wuerzburg, Federal Republic of Germany.

Biological Trace Element Research
|January 1, 1988
PubMed
Summary

Long-term total parenteral nutrition (TPN) can lead to selenium deficiency, particularly in infants. Supplementation is recommended, with dosages correlated to protein intake for optimal selenium balance and repletion.

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Area of Science:

  • Clinical Nutrition
  • Trace Element Metabolism

Background:

  • Selenium deficiency is a risk in chronic malnutrition and long-term total parenteral nutrition (TPN).
  • Observed critically low plasma selenium levels in infants on TPN, comparable to Keshan disease patients.
  • Low selenium correlated with reduced glutathione peroxidase activity, a key antioxidant enzyme.

Purpose of the Study:

  • To investigate selenium status in patients receiving long-term TPN.
  • To establish evidence-based recommendations for selenium supplementation in TPN.
  • To discuss optimal selenium dosage and forms for TPN solutions.

Main Methods:

  • Clinical observation of plasma selenium levels and glutathione peroxidase activity in infants on TPN.
  • Literature review of clinical cases of selenium deficiency.
  • Proposal of dosage recommendations based on protein supply.

Main Results:

  • Identified low plasma selenium levels in infants on long-term TPN.
  • While overt deficiency symptoms were absent in observed patients, literature supports the need for supplementation.
  • Proposed adequate selenium dosage for balance (0.5-1.0 µg/g protein) and repletion (up to 3 µg/g protein).

Conclusions:

  • Long-term TPN necessitates attention to selenium status due to deficiency risks.
  • Selenium supplementation in TPN is crucial, with dosage linked to protein intake.
  • Further discussion on the merits of selenite versus selenomethionine for TPN is warranted.

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