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Experimental study on interactions between selenium and tin in mice.

M Chiba1, N Kamiya, M Kikuchi

  • 1Department of Hygiene, Juntendo University School of Medicine, Tokyo, Japan.

Biological Trace Element Research
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Simultaneous tin (Sn) and selenium (Se) administration in mice increased body accumulation of both elements. Selenium altered tin distribution, suppressing bone and liver concentrations while increasing spleen and pancreas levels.

Area of Science:

  • Toxicology
  • Biochemistry
  • Trace Element Metabolism

Background:

  • Tin (Sn) and selenium (Se) are essential trace elements with complex biological interactions.
  • Understanding their organ distribution and excretion is crucial for assessing potential toxicity and therapeutic effects.

Purpose of the Study:

  • To investigate the organ distribution and excretion of tin and selenium when administered individually and simultaneously in mice.
  • To determine the impact of co-administration on the accumulation and distribution patterns of these elements.

Main Methods:

  • Four groups of mice were used: control, tin (Sn) injection, selenium (Se) injection, and combined Sn and Se injection.
  • Injections were administered daily for 12 consecutive days.
  • Organ distribution and urinary/fecal excretion of Sn and Se were quantified.

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Main Results:

  • Simultaneous Sn and Se administration enhanced the body accumulation of both elements compared to individual administration.
  • Tin excretion was reduced when co-administered with selenium (10.9% Sn vs. 14.1% in Sn-only group).
  • Selenium excretion was also reduced with co-administration (37.5% Se vs. 46.2% in Se-only group).
  • Tin distribution was altered by selenium: bone and liver concentrations decreased, while spleen and pancreas concentrations increased.
  • Selenium administration alone had minimal effects on selenium organ concentrations.
  • No chemical reduction of selenite by stannous chloride was observed in plasma.

Conclusions:

  • Co-administration of tin and selenium alters their individual pharmacokinetic profiles and organ distribution in mice.
  • Selenium significantly modifies tin's tissue accumulation, suggesting a complex interplay between these elements.
  • Further research is warranted to elucidate the mechanisms underlying these interactions and their toxicological implications.