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Related Experiment Video

Updated: Apr 29, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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DNA nanotechnology based on i-motif structures.

Yuanchen Dong1, Zhongqiang Yang, Dongsheng Liu

  • 1Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University , Beijing 100084, China.

Accounts of Chemical Research
|May 22, 2014
PubMed
Summary
This summary is machine-generated.

Researchers developed novel DNA molecular motors and devices using i-motif structures. These pH-responsive motors offer millisecond speeds and enable advanced applications in smart materials and in vivo studies.

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Area of Science:

  • * Nanotechnology
  • * Molecular Biology
  • * Materials Science

Background:

  • * Biological processes occur at the nanoscale, making energy and material transport mechanisms challenging to study.
  • * Artificial molecular systems, particularly DNA nanotechnology based on i-motif structures, are investigated to mimic biological processes.
  • * The i-motif is a DNA quadruplex stabilized by C·CH(+) base pairs under slightly acidic conditions.

Purpose of the Study:

  • * To summarize recent advances in functional DNA nanotechnology utilizing i-motif structures.
  • * To highlight the development and applications of pH-driven DNA molecular motors.
  • * To explore the potential of i-motif based DNA nanostructures in creating novel molecular devices and materials.

Main Methods:

  • * Investigated DNA i-motif structures for their unique pH-responsive properties.
  • * Designed and constructed DNA molecular motors capable of pH-driven operation.
  • * Integrated i-motif based motors into DNA nanostructures for diverse applications, including smart surfaces, nanopores, logic gates, and hydrogels.
  • * Explored light and electricity-driven DNA motors for integration with silicon nanodevices.

Main Results:

  • * Developed the first DNA molecular motor driven by pH changes, exhibiting millisecond running speeds comparable to natural protein motors.
  • * Demonstrated the ability to combine motor outputs to drive macroscopic structures like cantilevers.
  • * Created functional DNA molecular devices, including switchable smart surfaces, pH-triggered nanopores, molecular logic gates, and DNA nanosprings.
  • * Fabricated a fast-responding pure DNA supramolecular hydrogel with unique non-swelling properties.
  • * Showcased the utility of i-motif structures in creating 1D nanowires and 3D DNA structures.

Conclusions:

  • * DNA nanotechnology based on i-motif structures offers versatile platforms for creating advanced molecular motors and devices.
  • * These DNA-based systems show significant potential for applications in smart materials, tissue engineering, and in vivo studies.
  • * Further research in DNA nanotechnology will deepen the understanding of nanoscale energy and material transport, driving innovation across multiple scientific fields.