Related Experiment Video

Updated: Apr 29, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

12.9K

MicroRNAs as regulators of cutaneous wound healing

Wing-Fu Lai1, Parco M Siu

  • 1Division in Anatomy and Developmental Biology, Department of Oral Biology, College of Dentistry, Yonsei University, Seoul, Republic of Korea.

Journal of Biosciences
|May 22, 2014
PubMed

Insights

MicroRNAs (miRNAs) are crucial gene regulators with roles in skin. This review explores their significance in cutaneous wound healing and the potential for miRNA-based therapies.

Area of Science:

  • Molecular Biology
  • Dermatology
  • Regenerative Medicine

Background:

  • MicroRNAs (miRNAs) are key post-transcriptional gene regulators.
  • miRNAs play vital roles in embryonic development and skin physiology.
  • The specific roles of miRNAs in cutaneous wound healing remain largely unexplored.

Purpose of the Study:

  • To review existing evidence on miRNA functions in wound healing.
  • To highlight prospects and challenges for miRNA-based wound therapies.
  • To elucidate the potential of miRNA-targeted treatments for wound care.

Main Methods:

  • Literature review of current research on miRNAs and wound healing.
  • Analysis of physiological processes relevant to cutaneous repair.
  • Discussion of nucleic acid transfer and miRNA modulation technologies.

Main Results:

  • miRNAs are implicated in various physiological processes relevant to wound healing.
  • Significant gaps exist in understanding specific miRNA functions during skin repair.
  • Existing technologies support the development of miRNA-based interventions.

Conclusions:

  • Clarifying miRNA roles in wound healing is critical.
  • miRNA-targeted therapies offer promising new avenues for wound care.
  • Further research is needed to translate miRNA discoveries into clinical applications.

More Related Videos

Demonstration of the Rat Ischemic Skin Wound Model08:35

Demonstration of the Rat Ischemic Skin Wound Model

Published on: April 1, 2015

22.0K
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

9.2K

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.4K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
1.8K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.1K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
93