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Updated: Apr 29, 2026

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
Published on: May 16, 2020
Probody therapeutics for targeting antibodies to diseased tissue
Krishna R Polu1, Henry B Lowman
1CytomX Therapeutics, Inc. , 343 Oyster Point Boulevard, South San Francisco, CA 94080 , USA henry@cytomx.com.
Abstract:
Probodies are proteolytically activated antibodies engineered to remain inert until activated locally in diseased tissue. In principle, any therapeutic antibody can be converted into Probody™ form. In this perspective, we highlight the emerging therapeutic potential of the Probody approach in the form of conventional IgG-based Probodies as well as in the form of 'empowered Probody' formats such as Probody-drug conjugates.
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