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Updated: Apr 29, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Glycopeptide synthesis on an ionic liquid support.

Changgeng Li¹, Zhenxing Zhang, Qian Duan

¹CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences , Chaoyang District, Beijing 100101, China.

Organic Letters

|May 22, 2014

Summary

This summary is machine-generated.

A novel ionic liquid-supported method efficiently synthesizes glycopeptides in high yields. This approach minimizes reagent use and eliminates the need for chromatographic purification, advancing peptide and oligosaccharide synthesis.

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Last Updated: Apr 29, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

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Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

Published on: February 21, 2018

Area of Science:

Organic Chemistry
Synthetic Chemistry
Biochemistry

Background:

Glycopeptide synthesis is crucial for understanding biological processes.
Existing synthetic methods often require excess reagents and extensive purification.
Ionic liquid-supported synthesis offers potential advantages in efficiency and sustainability.

Purpose of the Study:

To develop an efficient ionic liquid-supported synthetic method for glycopeptide construction.
To demonstrate a high-yield synthesis that minimizes reagent usage.
To provide a purification-free approach for glycopeptide synthesis.

Main Methods:

Utilized an ionic liquid as a support for solid-phase synthesis.
Developed a streamlined procedure for glycopeptide assembly.
Focused on high-yield coupling and deprotection steps.

Main Results:

Achieved high yields in glycopeptide synthesis.
Significantly reduced the need for excess reagents.
Eliminated the requirement for chromatographic purification.

Conclusions:

The reported ionic liquid-supported method is a valuable addition to glycopeptide synthesis.
This approach offers an efficient and potentially greener alternative to current methods.
The method is applicable to both oligosaccharide and peptide synthesis.