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Related Experiment Video

Updated: Apr 29, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

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Published on: January 30, 2014

Neuroinflammation: microglial activation during sepsis.

Monique Michels, Lucineia G Danielski, Felipe Dal-Pizzol

¹Programa de Pos Graduacao em Ciencias da Saude, Universidade do Sul de Santa Catarina, Tubarao, SC, Brazil, Avenida Jose Acacio Moreira, 787, 88704-900. fabricia.petronilho@unisul.br.

Current Neurovascular Research

|May 22, 2014

Summary

Microglia, the brain's immune cells, become activated during sepsis, contributing to neuroinflammation and brain damage. Understanding their role is key to addressing sepsis-associated encephalopathy.

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Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

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Published on: February 16, 2018

Area of Science:

Neuroscience
Immunology
Toxicology

Background:

Neuroinflammation is implicated in both acute brain damage and chronic neurological diseases.
Microglia, the central nervous system (CNS) resident immune cells, function similarly to peripheral macrophages.
Microglial activation releases cytokines and chemokines to clear extracellular toxins, but can also contribute to CNS damage.

Purpose of the Study:

To elucidate the critical role of microglia in sepsis-induced neuroinflammation.
To describe the cellular mechanisms underlying microglial activation during sepsis.
To highlight the relevance of microglia in neurotoxicology, particularly in the context of septic encephalopathy.

Main Methods:

This is a review article, synthesizing existing research on microglia and sepsis.
Focuses on cellular mechanisms of microglial activation.
Examines the relationship between microglia and neuroinflammation in sepsis.

Main Results:

Microglial activation during sepsis leads to the production of inflammatory mediators.
This activation can compromise the blood-brain barrier integrity.
Reactive oxygen species produced by activated microglia contribute to CNS damage progression.

Conclusions:

Microglia play a significant role in the neuroinflammatory processes associated with sepsis.
Understanding microglial activation pathways is crucial for developing therapeutic strategies for septic encephalopathy.
Further research into microglia-neuroinflammation interactions in sepsis is warranted.