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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNAs and cancer; an overview

Lutfi Tutar, Esen Tutar, Yusuf Tutar1

  • 1Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, Sivas, Turkey, 58140. ytutar@cumhuriyet.edu.tr.

Current Pharmaceutical Biotechnology
|May 22, 2014
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in cellular processes and cancer. This review highlights their roles as cancer biomarkers and therapeutic targets, emphasizing recent advancements.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNAs regulating cellular functions.
  • Aberrant miRNA expression is implicated in various cancers, acting as oncogenes or tumor suppressors.
  • MiRNAs show promise as diagnostic and prognostic biomarkers in oncology.

Purpose of the Study:

  • To review the latest discoveries in miRNA research related to cancer.
  • To explore the role of miRNAs as biomarkers for cancer diagnosis and prognosis.
  • To discuss the therapeutic potential of modulating miRNA activity in cancer treatment.

Main Methods:

  • Literature review of recent scientific publications on miRNAs in cancer.
  • Analysis of studies investigating miRNA functions as oncogenes and tumor suppressors.
  • Examination of research on miRNA-based biomarkers and therapeutic strategies.

Main Results:

  • MiRNAs are crucial in cancer development and progression.
  • Specific miRNAs can serve as reliable biomarkers for cancer detection and outcome prediction.
  • Therapeutic strategies targeting miRNAs (mimics and antagonists) are advancing for clinical application.

Conclusions:

  • MiRNAs represent a significant area of cancer research with diagnostic and therapeutic implications.
  • Further investigation into miRNA mechanisms and clinical applications is warranted.
  • Modulating miRNA activity offers a promising avenue for novel cancer therapies.

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