Jove
Visualize
Contact Us

Related Experiment Videos

Fatal methylene blue associated serotonin toxicity.

W M C Top1, P K Gillman, C J de Langen

  • 1Department of Internal Medicine, Bethesda Hospital - Care Group Leveste Middenveld, Hoogeveen, the Netherlands.

The Netherlands Journal of Medicine
|May 22, 2014
PubMed
Summary

A fatal case of serotonin toxicity occurred due to methylene blue and venlafaxine interaction. Stopping serotonin re-uptake inhibitors before anesthesia can prevent this serious drug interaction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fetal and post-natal outcomes in offspring after intrauterine metformin exposure: A systematic review and meta-analysis of animal experiments.

Diabetic medicine : a journal of the British Diabetic Association·2023
Same author

Characteristics of high- and low-risk individuals in the PRIORITY study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

SUBSTANCES RELATED TO 5-HYDROXYTRYPTAMINE IN PLASMA AND IN LUMBAR AND VENTRICULAR FLUIDS OF PSYCHIATRIC PATIENTS.

Acta psychiatrica Scandinavica·2017
Same author

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.

Clinical pharmacology and therapeutics·2016
Same author

Long-term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial.

Journal of internal medicine·2013
Same author

Diabetes specialist nurse as main care provider for patients with type 2 diabetes.

The Netherlands journal of medicine·2009
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Pharmacology
  • Toxicology
  • Anesthesiology

Background:

  • Serotonin toxicity is a potentially life-threatening condition.
  • Methylene blue is a medication that can interact with serotonergic drugs.
  • Venlafaxine is a common antidepressant that increases serotonin levels.

Observation:

  • This report details a fatal outcome from serotonin toxicity.
  • The toxicity was triggered by the combined use of methylene blue and venlafaxine.
  • The patient presented after general anesthesia, complicating the diagnosis.

Findings:

  • Methylene blue-induced serotonin toxicity is typically mild.
  • This case represents a severe, fatal presentation of this interaction.
  • Discontinuation of serotonergic agents prior to anesthesia is crucial.

Related Experiment Videos

Implications:

  • Healthcare providers must be aware of this severe drug interaction.
  • Careful medication review is essential before anesthesia, especially with serotonergic agents.
  • Preventing serotonin toxicity through medication management is critical for patient safety.