[The post-transcriptional regulation of the DNA damage response]

Area of Science:

• Molecular Biology
• Cell Biology
• Genetics

Context:

• The DNA damage response (DDR) is a critical cellular network activated by DNA damage to halt cell division and initiate repair.
• Research traditionally focused on transcriptional and protein modification aspects of DDR.
• Recent attention has shifted towards the roles of mRNA stability and translation in DDR.

Purpose:

• To review recent findings on the post-transcriptional regulation of the DNA damage response (DDR).
• To highlight the involvement of microRNAs and RNA-binding proteins (RBPs) in DDR.
• To discuss how these molecules contribute to genome protection.

Summary:

• MicroRNAs and RBPs are increasingly recognized for their roles in the DDR.
• These molecules regulate DDR through post-transcriptional mechanisms, affecting mRNA stability and translation.
• Their collective action is vital for maintaining genomic integrity following DNA damage.

Impact:

• Advances understanding of DDR regulation beyond transcriptional control.
• Identifies novel targets for therapeutic interventions in diseases involving DNA damage.
• Provides insights into the complex interplay of RNA molecules in cellular stress responses.