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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.5K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:46

Epigenetic Regulation

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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

Histone Modification

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Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

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Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
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Related Experiment Video

Updated: Apr 29, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
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[DNA methylation and demethylation: current status and future perspective].

Deng Dajun1

  • 1Peking University Cancer Hospital and Institute, Beijing 100142, China.

Yi Chuan = Hereditas
|May 22, 2014
PubMed
Summary

DNA methylation is crucial for gene regulation, development, and disease. Recent advances reveal new mechanisms and its potential as a biomarker and therapeutic target in epigenetics research.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Genetics

Context:

  • DNA methylation is a key epigenetic mechanism regulating gene expression.
  • It plays vital roles in cellular processes like differentiation, development, and disease.
  • Epigenetics research is rapidly advancing our understanding of DNA methylation.

Purpose:

  • To summarize recent significant findings in DNA methylation research.
  • To highlight the discovery of TETs-mediated cytosine hydroxymethylation and its role in development.
  • To discuss the mechanisms of DNA demethylation, pattern establishment, and maintenance.

Summary:

  • Recent discoveries include TETs-catalyzed cytosine hydroxymethylation and its functions in early embryonic development.
  • The interplay between DNA methylation, histone modifications, chromatin structure, and non-coding RNAs is increasingly understood.

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Targeted DNA Methylation Analysis by Next-generation Sequencing
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Targeted DNA Methylation Analysis by Next-generation Sequencing

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Related Experiment Videos

Last Updated: Apr 29, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

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Targeted DNA Methylation Analysis by Next-generation Sequencing
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  • Active and passive DNA demethylation processes have been further elucidated.

    • Impact:

    • DNA methylation is emerging as a critical biomarker for various conditions.
    • It presents new therapeutic targets for diseases.
    • Advances in understanding DNA methylation pave the way for novel diagnostic and treatment strategies.