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Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

3.7K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

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Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
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Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

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Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

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The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
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A Novel Method: Super-selective Adrenal Venous Sampling
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Primary adrenal sarcomatoid carcinoma.

Aftab S Shaikh1, Girish D Bakhshi1, Arshad S Khan1

  • 1Department of Surgery, Grant Medical College & Sir JJ Group of Hospitals , Mumbai, India.

Clinics and Practice
|May 22, 2014
PubMed
Summary

Adrenal sarcomatoid carcinoma is a rare, aggressive cancer. This case highlights its rapid progression and poor prognosis, emphasizing the need for further research into effective treatments for this challenging diagnosis.

Keywords:
adrenalcarcinomasarcoma

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Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Adrenal sarcomatoid carcinoma is an exceptionally rare adrenal gland neoplasm.
  • These tumors are characterized by aggressive behavior and rapid progression.

Observation:

  • A case of a 62-year-old female with a non-functional right adrenal sarcomatoid carcinoma is presented.
  • Initial presentation showed no radiological evidence of locoregional metastases.
  • The patient underwent right adrenalectomy.

Findings:

  • Post-operative follow-up revealed para-aortic lymphadenopathy and a contralateral adrenal mass.
  • The patient's disease progressed rapidly, leading to death within months.
  • This underscores the aggressive nature and poor prognosis associated with adrenal sarcomatoid carcinoma.

Implications:

  • Limited case reports necessitate further investigation into adrenal sarcomatoid carcinoma.
  • Understanding the clinical behavior and metastatic potential is crucial for improved patient outcomes.
  • This case contributes to the sparse literature on this rare malignancy.