Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferons: from molecular biology to man. Part 2. Interferons and cell function.

F R Balkwill1

  • 1Interferon Laboratory, Imperial Cancer Research Fund, London, UK.

Microbiological Sciences
|August 1, 1986
PubMed
Summary

Interferons are key antiviral proteins. This study details how interferons modify cell behavior, building upon previous genetic and molecular insights into the interferon system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics.

Journal of the mechanical behavior of biomedical materials·2016
Same author

A clinical study assessing the tolerability and biological effects of infliximab, a TNF-alpha inhibitor, in patients with advanced cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2008
Same author

Epithelial cancer cell migration: a role for chemokine receptors?

Cancer research·2001
Same author

Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation--a potential mechanism.

European journal of immunology·2001
Same author

Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model.

British journal of cancer·2000
Same author

Re: Possible role of ovarian epithelial inflammation in ovarian cancer.

Journal of the National Cancer Institute·2000

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • The interferon system plays a crucial role in innate immunity.
  • Part 1 of this series elucidated the genetic and molecular underpinnings of interferon production and function.

Purpose of the Study:

  • To describe the mechanisms by which interferons modulate cellular behavior.
  • To expand upon the foundational knowledge of the interferon system presented in Part 1.

Main Methods:

  • Review of existing literature on interferon signaling pathways.
  • Analysis of cellular responses to interferon treatment in various cell types.

Main Results:

  • Interferons induce significant changes in gene expression within treated cells.
  • These alterations impact diverse cellular processes, including cell cycle regulation, differentiation, and apoptosis.
  • Specific signaling cascades activated by interferons were identified.

Conclusions:

  • Interferons are potent regulators of cell behavior with broad biological implications.
  • Understanding interferon-mediated cellular alterations is critical for developing antiviral and anticancer therapies.

Related Experiment Videos