A need for new generation antibiotics against MRSA resistant bacteria

Area of Science:

• Microbiology
• Medicinal Chemistry
• Pharmacology

Background:

• Antibiotic resistance, particularly from methicillin-resistant Staphylococcus aureus (MRSA), necessitates the development of new antimicrobial agents.
• Limited availability of novel antibiotics with distinct mechanisms of action poses a significant challenge in combating resistant infections.

Purpose of the Study:

• To evaluate the potential of synthetic guanidine-based polymers, specifically Akacid, as a new class of antibiotics.
• To assess the efficacy and safety profile of Akacid against a broad spectrum of microorganisms, including resistant strains.

Main Methods:

• Synthesis and characterization of novel guanidine-based polymers (Akacid).
• In vitro antimicrobial susceptibility testing against various bacterial and microbial species, including MRSA.
• Assessment of safety and tolerability through application studies on skin, mucosa, and eyes.

Main Results:

• Akacid demonstrated high potency against a wide range of microorganisms, including challenging resistant strains.
• The synthetic polymers exhibited a favorable safety profile with excellent tolerability on sensitive tissues like skin, mucosa, and eyes.
• These findings highlight the potential of Akacid as a versatile antimicrobial agent.

Conclusions:

• Synthetic guanidine-based polymers represent a promising new avenue for antibiotic development.
• Akacid shows significant potential for both topical and systemic applications in human and veterinary medicine, especially for treating infections caused by resistant microorganisms.