Related Experiment Video
Updated: Apr 29, 2026

07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
17.5K
Scurvy revealed by difficulty walking: three cases in young children
Maleewan Kitcharoensakkul1, Christa G Schulz, Rachel Kassel
1From the Departments of *Pediatrics and †Radiology, Washington University School of Medicine, St Louis, MO.
Summary
Scurvy, a vitamin C deficiency, can cause leg pain and difficulty walking in children, even without typical gum symptoms. Early diagnosis and vitamin C treatment lead to recovery.
Area of Science:
- Pediatrics
- Nutrition
- Rheumatology
Background:
- Scurvy, caused by ascorbic acid deficiency, is rare in developed nations.
- It classically presents with lower-extremity pain and reluctance to ambulate in children.
- Recognition and diagnosis have declined due to its rarity.
Observation:
- Three young children presented with difficulty walking and leg pain.
- Only one patient exhibited gingival lesions.
- Extensive hematologic and rheumatologic workups preceded the scurvy diagnosis in two cases.
Findings:
- All patients had limited fruit and vegetable intake due to oral aversion; one had autism.
- Radiographic examination revealed long bone abnormalities in all three.
- Concomitant vitamin D deficiency was noted in all cases.
Implications:
- Rheumatologists should consider scurvy in nonambulatory children, even with atypical presentations.
- Dietary history, focusing on fruit and vegetable intake, is crucial.
- Prompt vitamin C supplementation resolves symptoms and improves mobility.
More Related Videos
Related Concept Videos
Vitamins
2.7K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.7K
Bone Disorders
8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
Type I Diabetes III: Clinical Manifestations
26
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the...
26
Changes in the Appendicular Skeleton with Age
3.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.2K
Inborn Errors of Metabolism
1.1K
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
1.1K
Pyloric Obstruction
39
Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
39

