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Updated: Apr 29, 2026
Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
Published on: April 18, 2015
Optimization of MR diffusion-weighted imaging acquisitions for pancreatic cancer at 3.0T
Xiuzhong Yao1, Tiantao Kuang2, Li Wu1
1Department of Radiology, Zhongshan Hospital of Fudan University, No. 138, Fenglin Road, Xuhui District, Shanghai 200032, China; Department of Medical Image, Shanghai Medical College of Fudan University, Shanghai Institute of Medical Imaging, No. 138, Fenglin Road, Xuhui District, Shanghai 200032, China.
Objectives:
To investigate and optimize diffusion-weighted imaging (DWI) acquisitions for pancreatic cancer at 3.0T.
Methods:
Forty-five patients with pancreatic cancer were examined by four DWI acquisitions with b values=0 and 600s/mm(2) at 3.0T, including breath-holding DWI (BH-DWI), respiratory-triggered DWI (TRIG-DWI), respiratory-triggered DWI with inversion-recovery technique (TRIGIR-DWI), and free-breathing DWI with inversion-recovery technique (FBIR-DWI). Artifacts, contrast ratio (CR), contrast-to-noise ratio (CNR) and apparent diffusion coefficient (ADC) of pancreatic cancer were statistically compared among DWI acquisitions.
Results:
TRIGIR-DWI displayed the lowest artifacts and highest CR compared to other DWI acquisitions. CNRs of pancreatic cancer in TRIG-DWI and TRIGIR-DWI were statistically higher than that in FBIR-DWI and BH-DWI. Different ADCs between pancreatic cancer and noncancerous pancreatic tissues were noticed by a paired-samples T test in TRIG-DWI (p=0.017), TRIGIR-DWI (p=0.00001) and FBIR-DWI (p=0.000041).
Conclusions:
TRIGIR-DWI may be the optimal acquisition of DWI for pancreatic cancer at 3.0T.
