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A preliminary trial of high-dose intravenous immunoglobulin to a patient with euthyroid ophthalmopathy
E K Philipsen1, S Larsen, P Helin
1Department of Biophysics, Statens Seruminstitut, Copenhagen, Denmark.
A patient with serious euthyroid infiltrative ophthalmopathy was treated with oral glucocorticoids for five years. The course of the disorder was characterized by recurrent exacerbations during attempts to reduce the dose of systemic glucocorticoids. Intravenous infusion with high-dose immunoglobulin gave immediately favourable regression of the lesion, without side-effects. Possible modes of action of high-dose immunoglobulin treatment are discussed.
A patient with serious euthyroid infiltrative ophthalmopathy was treated with oral glucocorticoids for five years. The course of the disorder was characterized by recurrent exacerbations during attempts to reduce the dose of systemic glucocorticoids. Intravenous infusion with high-dose immunoglobulin gave immediately favourable regression of the lesion, without side-effects. Possible modes of action of high-dose immunoglobulin treatment are discussed.