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Updated: Jul 15, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Hyperpigmentation in Graves' disease
1Department of Medicine, Baylor College of Medicine, Houston, Texas.
Abstract:
Thirty-two consecutive patients presenting with Graves' disease were divided into two groups, black (Group I) and non-black (Group II), and observed for the occurrence of hyperpigmentation. The overall incidence of hyperpigmentation in subjects with Graves' disease was 38 percent, with 12 of 14 Group I patients and 0 of 18 Group II patients demonstrating this finding. Serum thyroxine was higher in Group I than in Group II. We conclude that hyperpigmentation is common in black patients with Graves' disease.
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