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Related Experiment Videos

Trace amines and cocaine abuse.

Jun-Xu Li1

  • 1Department of Pharmacology and Toxicology, University at Buffalo , Buffalo, New York 14214, United States.

ACS Chemical Neuroscience
|May 23, 2014
PubMed
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Trace amine-associated receptor 1 (TAAR 1) shows potential as a novel therapeutic target for cocaine addiction. Emerging data suggest TAAR 1 acts as a molecular brake, controlling cocaine

Area of Science:

  • Neuroscience
  • Pharmacology
  • Addiction Research

Background:

  • Cocaine addiction presents a significant clinical challenge.
  • Current pharmacotherapy options for cocaine addiction are limited.
  • The dopaminergic system is critically involved in stimulant abuse.

Purpose of the Study:

  • To discuss the emerging role of Trace amine-associated receptor 1 (TAAR 1) in cocaine addiction.
  • To explore TAAR 1 as a potential therapeutic target for modulating the dopaminergic system and treating stimulant abuse.

Main Methods:

  • This is a viewpoint discussion based on emerging scientific data.
  • Analysis of current research on TAAR 1 function and its relation to addiction.

Main Results:

Related Experiment Videos

  • Emerging data suggest TAAR 1 acts as a molecular "brake" on addiction-related effects of cocaine.
  • TAAR 1's modulation of the dopaminergic system is key to its potential therapeutic role.

Conclusions:

  • TAAR 1 represents a promising novel drug target for cocaine addiction pharmacotherapy.
  • Targeting TAAR 1 could lead to the development of efficacious treatments for cocaine addiction.