Evol and ProDy for bridging protein sequence evolution and structural dynamics
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Updated: Apr 29, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
Ahmet Bakan1, Anindita Dutta1, Wenzhi Mao1
1Department of Computational and Systems Biology, and Clinical & Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Unlabelled:
Correlations between sequence evolution and structural dynamics are of utmost importance in understanding the molecular mechanisms of function and their evolution. We have integrated Evol, a new package for fast and efficient comparative analysis of evolutionary patterns and conformational dynamics, into ProDy, a computational toolbox designed for inferring protein dynamics from experimental and theoretical data. Using information-theoretic approaches, Evol coanalyzes conservation and coevolution profiles extracted from multiple sequence alignments of protein families with their inferred dynamics.
Availability And Implementation:
ProDy and Evol are open-source and freely available under MIT License from http://prody.csb.pitt.edu/.
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