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[Histopathological and immunohistochemical studies on mucous cysts]
Meikai Daigaku Shigaku Zasshi = the Journal of Meikai University School of Dentistry
|January 1, 1989
Summary
This study examined oral mucous cysts, finding extravasation types more common and granulation tissue in many walls. Immunohistochemistry revealed specific markers in cyst contents and salivary glands, aiding in understanding cyst composition.
Area of Science:
- Oral pathology
- Histochemistry
- Immunohistochemistry
Context:
- Oral mucous cysts are common lesions.
- Understanding their histopathology and molecular composition is crucial for diagnosis and management.
Purpose:
- To investigate the histopathology, mucopolysaccharide content, and immunohistochemical markers of oral mucous cysts.
- To differentiate between retention and extravasation types and analyze associated salivary gland changes.
Summary:
- Histopathological analysis revealed extravasation type cysts were more prevalent (64/90 cases). Cystic walls often consisted of granulation tissue (50/90 cases) with mild inflammation.
- Histochemical staining showed intense mucopolysaccharide presence in cyst contents and mucous cells (PAS, Alcian Blue).
- Immunohistochemistry identified secretory component (SC), alpha-amylase (Am), IgA, and lysozyme (Ly) in cyst contents, while lactoferrin (Lf) and keratin (Kr) were negative. Serous acinar cells showed strong reactivity for SC, Ly, and Am.
Impact:
- Provides detailed histopathological and molecular characterization of oral mucous cysts.
- Differentiates between cyst types and associated salivary gland alterations.
- Contributes to a better understanding of the pathogenesis and composition of oral mucous cysts.