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The Standard PREanalytical Code (SPREC) was updated to version 2.0 to improve biospecimen quality documentation. This revision incorporates new technological advancements and enhances communication for research biospecimens.

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Area of Science:

  • Biospecimen Science
  • Research Quality Management
  • Biobanking Informatics

Background:

  • The initial Standard PREanalytical Code (SPREC) was established in 2009 by the International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group.
  • SPREC aimed to standardize the documentation and communication of critical preanalytical variables for research biospecimens.
  • Advancements in biospecimen research necessitate an updated code to reflect current technological capabilities.

Purpose of the Study:

  • To present the updated Standard PREanalytical Code (SPREC) version 2.0.
  • To incorporate recent technological developments and fine-tune existing elements within the SPREC.
  • To enhance the documentation and communication of biospecimen preanalytical quality parameters for research.

Main Methods:

  • Revision and expansion of the original SPREC elements.
  • Development of an interface with the Biospecimen Reporting for Improved Study Quality (BRISQ) guidelines.
  • Creation of informatics solutions for practical SPREC implementation.
  • Addition of a glossary for SPREC-related definitions.

Main Results:

  • SPREC version 2.0 offers expanded options to accommodate new technologies.
  • Existing SPREC elements have been refined for improved clarity and utility.
  • Integration pathways with BRISQ and informatics support have been established.

Conclusions:

  • SPREC version 2.0 provides a more comprehensive framework for documenting biospecimen preanalytical quality.
  • The updated code supports current research needs and technological advancements in biobanking.
  • Enhanced standardization through SPREC 2.0 facilitates better communication and data integrity in biospecimen research.