Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

906
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
906
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

26
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
26
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

4.4K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
4.4K
Pain01:20

Pain

2.1K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
2.1K
Abdominal Regions and Quadrants01:19

Abdominal Regions and Quadrants

17.3K
To promote clear communication, for instance, about the location of a patient's abdominal pain or a suspicious mass, anatomists and clinicians typically use imaginary lines to categorize the abdominopelvic cavity into either four quadrants or nine regions to identify organs in the cavity.
The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersects at the patient's umbilicus (navel). The four...
17.3K
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

35
Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant...
35

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Journal of Pain Enters a New Era.

The journal of pain·2020
Same author

Physiology of Visceral Pain.

Comprehensive Physiology·2016
Same author

Chronic Prostatitis Induces Bladder Hypersensitivity and Sensitizes Bladder Afferents in the Mouse.

The Journal of urology·2016
Same author

Optogenetic activation of mechanically insensitive afferents in mouse colorectum reveals chemosensitivity.

American journal of physiology. Gastrointestinal and liver physiology·2016
Same author

A novel role for follistatin in hypersensitivity following cystitis.

Neurourology and urodynamics·2015
Same author

Roles of isolectin B4-binding afferents in colorectal mechanical nociception.

Pain·2015

Related Experiment Video

Updated: Apr 29, 2026

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

19.6K

Visceral pain.

Erica S Schwartz1, G F Gebhart

  • 1Center for Pain Research, Department of Anesthesiology, School of Medicine, University of Pittsburgh, W1444 BST-Starzl, 200 Lothrop St., Pittsburgh, PA, 15213, USA.

Current Topics in Behavioral Neurosciences
|May 23, 2014
PubMed
Summary

Understanding visceral pain neurobiology is key. Animal models offer insights into visceral pain mechanisms, aiding future therapeutic development for this understudied area.

Area of Science:

  • Neuroscience
  • Pain Research
  • Physiology

Background:

  • Visceral pain differs from somatic pain due to unique innervation and stimulus response.
  • Understanding the neurobiology of visceral sensation is crucial for accurate modeling.
  • Visceral pain is an understudied area with significant clinical implications.

Purpose of the Study:

  • To highlight the importance of neurobiological principles in modeling visceral pain.
  • To differentiate visceral pain mechanisms from other pain types.
  • To emphasize the translational potential of animal models in visceral pain research.

Main Methods:

  • Review of neurobiological characteristics of visceral sensation.
  • Analysis of unique visceral pain stimuli and their effects.

More Related Videos

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

17.6K
Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

15.2K

Related Experiment Videos

Last Updated: Apr 29, 2026

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

19.6K
Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

17.6K
Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

15.2K
  • Examination of viscero-somatic and viscero-visceral convergence principles.

    • Main Results:

    • Visceral pain involves distinct neurobiological pathways and stimulus sensitivities compared to somatic pain.
    • Convergence principles (viscero-somatic, viscero-visceral) are fundamental to visceral pain.
    • Animal models provide valuable insights into basic science mechanisms.

    Conclusions:

    • Accurate modeling of visceral pain requires a deep understanding of its neurobiology.
    • Basic science knowledge from animal models can guide the development of novel therapeutics for visceral pain.
    • Further research into visceral pain mechanisms is essential for clinical advancement.