Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virtual Responsive Neurostimulation Implantation: From Intracranial Connectivity to Optimized Lead Placement.

medRxiv : the preprint server for health sciences·2026
Same author

Responsive stimulation of the thalamus for idiopathic generalized epilepsy: Results of the randomized controlled NAUTILUS trial through 18 months.

Epilepsia·2026
Same author

Postapproval Study for Brain-Responsive Neurostimulation for Drug-Resistant Focal Epilepsy: Three-Year Efficacy and Interim Safety Results.

Neurology·2026
Same author

Using vision transformers for electrographic seizure classification to aid physician review of intracranial electroencephalography recordings.

Frontiers in human neuroscience·2025
Same author

AI-Driven Electrographic Seizure Classification and Seizure Onset Detection Using Image- and Time-Series-Based Approaches.

IEEE transactions on bio-medical engineering·2025
Same author

Chronic thalamic recordings for idiopathic generalized epilepsy and Lennox-Gastaut syndrome: Ictal and interictal electrophysiological findings.

Epilepsia open·2025
Same journal

FGF17 synergistically targets neuronal survival and oligodendrogenesis to restore stroke deficits.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same journal

Sotagliflozin improves cognitive deficits and attenuates neuroinflammation of Alzheimer's disease.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same journal

Neurological complications of current and emerging CAR-T cell therapies.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same journal

Hemodynamics Beyond Ischemic Zone Underlies Early Neurological Deterioration in Minor Stroke with Large Vessel Occlusion.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same journal

Nervonic acid and the long arc of therapeutic hope in X-linked adrenoleukodystrophy.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
Same journal

Long-term efficacy of subthalamic nucleus deep brain stimulation in focal motor seizures and implications for candidate selection.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2026
See all related articles

Related Experiment Video

Updated: Apr 29, 2026

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
05:19

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

6.1K

Closed-loop neurostimulation: the clinical experience.

Felice T Sun1, Martha J Morrell

  • 1NeuroPace Inc., 445 N. Bernardo Avenue, Mountain View, CA, 94043, USA, fsun@neuropace.com.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|May 23, 2014
PubMed
Summary
This summary is machine-generated.

Closed-loop neurostimulation systems adapt therapy based on patient physiology, offering improved treatment for movement disorders, pain, and epilepsy. This review details clinical experiences with four advanced implantable closed-loop systems.

More Related Videos

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.8K
Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks
11:18

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

11.5K

Related Experiment Videos

Last Updated: Apr 29, 2026

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
05:19

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

6.1K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.8K
Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks
11:18

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

11.5K

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Medical Technology

Background:

  • Neurostimulation is a key therapy for neurological conditions like movement disorders, pain, and epilepsy.
  • Current neurostimulation predominantly uses open-loop systems with fixed parameters.
  • Closed-loop systems offer adaptive therapy, potentially enhancing efficacy and efficiency, but face design complexities.

Purpose of the Study:

  • To review the clinical experience of implantable closed-loop neurostimulation systems.
  • To explore the technological advancements enabling closed-loop neurostimulation.
  • To present the evolution and application of adaptive neurostimulation therapies.

Main Methods:

  • Review of clinical data from four implantable closed-loop neurostimulation systems.
  • Analysis of sensing, detection, and stimulation technologies.
  • Examination of historical development and current applications in pain, epilepsy, and Parkinson's disease.

Main Results:

  • Positional-adaptive spinal cord stimulation for pain management.
  • Responsive cortical stimulation and closed-loop vagus nerve stimulation for epilepsy.
  • Concurrent sensing and stimulation for Parkinson's disease treatment.
  • Demonstrated feasibility and clinical utility of adaptive neurostimulation.

Conclusions:

  • Closed-loop neurostimulation systems represent a significant advancement over open-loop approaches.
  • These adaptive systems show promise for more personalized and effective treatment of neurological disorders.
  • Further development and implementation of closed-loop technologies are crucial for future neurotherapeutics.