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Breast milk oligosaccharides: structure-function relationships in the neonate.
Jennifer T Smilowitz1, Carlito B Lebrilla, David A Mills
1Department of Food Science and Technology.
Annual Review of Nutrition
|May 23, 2014
Summary
Breast milk glycans are vital for infant gut and immune development. Advanced analysis reveals how glycan diversity impacts infant health and informs nutritional interventions.
Area of Science:
- Human biology
- Nutritional science
- Biochemistry
Background:
- Breast milk provides essential nutrition and bioactive components for infant development.
- Lactation offers insights into diet's role in shaping the infant gut microbiome.
- Milk glycans, though indigestible by infants, are crucial bioactive components.
Purpose of the Study:
- To review current technologies for analyzing milk glycans.
- To explore the structure-function relationships of milk glycans.
- To understand the impact of glycan diversity on neonatal health and nutrition.
Main Methods:
- Review of emerging analytical technologies for glycan analysis.
- Examination of scientific literature on milk glycan structure and function.
- Discussion of the implications of glycan diversity for infant health.
Main Results:
- Technological advancements enable more comprehensive and sensitive glycan analysis.
- Specific glycan structures are increasingly linked to biological functions.
- Inter- and intraindividual glycan diversity plays a significant role in infant development.
Conclusions:
- Understanding milk glycan diversity is key to optimizing early nutrition.
- Advanced glycan analysis facilitates the development of targeted health interventions.
- Knowledge of glycan structure-function enhances our understanding of neonatal health.
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