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DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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Related Experiment Video

Updated: Apr 29, 2026

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
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Chronodisruption, cell cycle checkpoints and DNA repair.

Rachel Ben-Shlomo

    Indian Journal of Experimental Biology
    |May 24, 2014
    PubMed
    Summary

    Chronodisruption, or disturbed light/dark cycles, may disrupt cell cycle regulation and DNA repair. This may increase cancer risk by interfering with cell cycle checkpoints.

    Area of Science:

    • Cellular Biology
    • Chronobiology
    • Cancer Research

    Background:

    • Chronodisruption, a disturbance in natural light-dark cycles, is potentially linked to cell cycle homeostasis disturbances.
    • The precise synchronization between circadian rhythms and mitosis remains unclear, though the circadian oscillator influences cell division pathways.
    • A molecular link between the circadian clock and DNA damage checkpoints in mammals has been identified.

    Purpose of the Study:

    • To review current findings on light pollution's influence on cell cycle checkpoints.
    • To explore the potential impact of chronodisruption on DNA repair mechanisms.
    • To discuss the association between circadian rhythm disruption and cell cycle control.

    Main Methods:

    • Literature review of studies on light pollution, circadian rhythms, and cell cycle regulation.

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  • Analysis of molecular links between circadian clocks and DNA damage checkpoints.
  • Examination of gene expression data related to cell cycle progression and tumorigenesis.

    • Main Results:

    • Light disruption is associated with impaired cell cycle homeostasis.
    • Disrupted cell cycle control is linked to cancer and accelerated malignant growth.
    • Light exposure during dark phases affects genes involved in cell cycle progression, proliferation, and tumorigenesis.

    Conclusions:

    • Chronodisruption may obstruct cell cycle checkpoints and DNA repair.
    • Interruption of cell cycle homeostasis by light pollution could contribute to cancer development.
    • Shift work involving circadian disruption is classified as possibly carcinogenic, highlighting the importance of light-dark regulation.