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Efficiency of pancreatic duct stenting therapy in children with chronic pancreatitis

Grzegorz Oracz1, Jan Pertkiewicz2, Jaroslaw Kierkus1

  • 1Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Warsaw, Poland.

Gastrointestinal Endoscopy
|May 24, 2014
PubMed

Insights

Pancreatic duct stenting effectively reduces pancreatitis episodes in children with chronic pancreatitis. This safe endoscopic therapy is recommended, particularly for hereditary cases and those with duct anomalies.

Area of Science:

  • Pediatric Gastroenterology
  • Endoscopic Interventions
  • Pancreatic Diseases

Background:

  • Chronic pancreatitis (CP) is a rare pediatric condition.
  • The efficacy of pancreatic duct stenting in children with CP remains largely uninvestigated.
  • Endoscopic retrograde cholangiopancreatography (ERCP) is frequently used in pediatric patients.

Purpose of the Study:

  • To evaluate the effectiveness of pancreatic duct stenting in managing pediatric chronic pancreatitis.
  • To assess the safety and outcomes of endoscopic therapy for CP in children.

Main Methods:

  • Retrospective analysis of 208 children with CP hospitalized between 1988 and 2012.
  • Involved 223 pancreatic duct stenting procedures performed via ERCP.
  • Compared pancreatitis episode frequency before and after endoscopic treatment.

Main Results:

  • A significant reduction in annual pancreatitis episodes was observed, decreasing from 1.75 to 0.23 post-treatment (P < .05).
  • Pancreatic duct stenting was frequently utilized in hereditary pancreatitis (61.5%) and in children with ductal anomalies (65%; P < .05).
  • The median number of stent replacements was 3, with a range of 1-21 procedures.

Conclusions:

  • Pancreatic duct stenting is a safe and effective therapeutic option for pediatric chronic pancreatitis.
  • The study recommends this endoscopic therapy, especially for children with hereditary pancreatitis.
  • Patients with anatomical abnormalities of the pancreatic duct may also benefit significantly from this intervention.
Abstract

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