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Related Experiment Videos

Abnormal thyroid function in hyperemesis gravidarum.

A Shulman1, M S Shapiro, C Bahary

  • 1Department of Obstetrics and Gynecology B, Meir Hospital, Sapir Medical Center, Kfar Saba, Israel.

Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1989
PubMed
Summary
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Thyroid dysfunction is common in hyperemesis gravidarum (HG). Some patients with persistent HG and abnormal thyroid tests may benefit from antithyroid agents, especially if hyperthyroidism is suspected.

Area of Science:

  • Endocrinology
  • Obstetrics

Background:

  • Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting during pregnancy.
  • Thyroid dysfunction can present asymptomatically or with subtle signs.

Purpose of the Study:

  • To evaluate thyroid function in women with hyperemesis gravidarum.
  • To determine the efficacy of conservative therapy and antithyroid agents in managing HG with thyroid abnormalities.

Main Methods:

  • Thyroid function tests, including free thyroxine (FT4) and thyrotropin-releasing hormone (TRH) stimulation tests, were performed on 41 women with HG.
  • Patients with persistent emesis and abnormal thyroid function received conservative therapy or antithyroid agents.

Main Results:

  • Eleven patients (27%) had elevated FT4 levels.

Related Experiment Videos

  • Four patients with persistent emesis and abnormal thyroid function were treated with antithyroid agents; three showed signs of hyperthyroidism.
  • TRH tests revealed abnormal TSH responses, indicating autonomous thyroid function in patients treated with antithyroid drugs and some untreated patients.

    • Conclusions:

    • Subtle hyperthyroidism may underlie some cases of HG.
    • Antithyroid agents should be considered for HG patients with persistent emesis and abnormal thyroid function tests after a week of conservative management.