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Gender differences in tumor and patient characteristics in those undergoing Mohs surgery
Kachiu C Lee1, H William Higgins, Olivia Linden
1*All the authors are affiliated with the Department of Dermatology, Brown University, Providence, Rhode Island.
Background:
Nonmelanoma skin cancer is the most common cancer in the United States, and when indicated, Mohs micrographic surgery (MMS) is an effective method for tumor removal. Few studies have focused on gender-specific characteristics among those undergoing MMS.
Objective:
To elucidate patient- and tumor-specific characteristics in female MMS patients.
Materials And Methods:
We performed a retrospective chart review of 12,344 consecutive patients undergoing MMS from 2005 to 2012.
Results:
There was a 1.5:1 male predominance in the presentation of basal cell carcinoma (BCC) for MMS. However, BCC comprised 72% of tumors in women compared with 63% in men. Presenting tumor sizes of BCCs were smaller in women (0.9 vs 1.2 cm, p < .01). Superficial BCCs were more common in women (p < .001). Women had fewer squamous cell carcinoma (p < .01) and squamous cell carcinoma in situ (p < .01). They were more likely to present with tumors on their legs and central facial areas, whereas men had more tumors on their scalps and ears. Plastic surgery referral was over twice as common in the female population (p < .01).
Conclusion:
In our data set, significant gender-specific differences were found in women compared with men undergoing MMS. These findings may be the result of discrepancies in sun exposure, protective behavior, and cosmetic concern.
Insights
Gender differences in Mohs micrographic surgery (MMS) reveal distinct characteristics for women. Women undergoing MMS for nonmelanoma skin cancer present with smaller basal cell carcinomas and fewer squamous cell carcinomas, often on legs and central face.
Area of Science:
- Dermatology
- Oncology
- Surgical Oncology
Background:
- Nonmelanoma skin cancer is the most prevalent cancer in the U.S.
- Mohs micrographic surgery (MMS) is a highly effective treatment for skin cancer removal.
- Limited research has explored gender-specific variations in patients undergoing MMS.
Purpose of the Study:
- To identify and analyze patient and tumor characteristics specific to women undergoing MMS.
- To compare these characteristics with those of male patients undergoing the same procedure.
Main Methods:
- A retrospective chart review was conducted.
- Data from 12,344 consecutive patients who underwent MMS between 2005 and 2012 were analyzed.
Main Results:
- Basal cell carcinoma (BCC) was more prevalent in women (72%) compared to men (63%), despite an overall male predominance (1.5:1).
- Women presented with smaller BCCs (0.9 cm vs. 1.2 cm) and a higher incidence of superficial BCCs.
- Women had fewer squamous cell carcinomas and were more likely to have tumors on their legs and central face, while men had more tumors on scalps and ears. Plastic surgery referral was also higher in women.
Conclusions:
- Significant gender-specific differences exist in patients undergoing MMS for nonmelanoma skin cancer.
- These disparities may stem from variations in sun exposure, protective behaviors, and cosmetic considerations between genders.
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