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Relationship of mismatch repair proteins and survivin in colon polyps and carcinomas

Marian Adamkov1, Martina Furjelová1, Jaroslav Horáček2

  • 1Department of Histology and Embryology, Jessenius Faculty of Medicine Martin, Comenius University Bratislava, Malá Hora 4, 036 01 Martin, Slovakia.

Acta Histochemica
|May 24, 2014
PubMed

Insights

Mismatch repair proteins (MMRP) and survivin are key prognostic markers in colon cancer. This study found a significant correlation between MMRP and survivin expression, suggesting MMRP may suppress survivin

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Mismatch repair (MMR) genes are crucial for DNA repair, and mutations can lead to cancer.
  • Survivin, an antiapoptotic protein, influences cell division, apoptosis, and angiogenesis.
  • Both MMR protein (MMRP) status and survivin expression are significant prognostic indicators.

Purpose of the Study:

  • To investigate the relationship between MMRP and survivin expression in colon lesions.
  • To analyze MMRP and survivin in colon carcinomas and polyps.

Main Methods:

  • Immunohistochemistry was used to assess MMRP (MLH1, MSH2, MSH6, PMS2) and survivin expression.
  • Expression levels, staining intensity, and percentage of labeled cells were analyzed.
  • Statistical analysis was performed to determine correlations.

Main Results:

  • In colon carcinomas, MMRP expression was high (88.5%-99.1%), while survivin was detected in 41.6% of cases.
  • All colon polyp samples showed positive MMRP expression, with only 15.7% positive for survivin.
  • A significant correlation was found between MMRP and survivin expression in assessed parameters.

Conclusions:

  • MMRP status and survivin expression are significantly correlated in colon lesions.
  • MMRP may suppress survivin's antiapoptotic function via p53 in early-grade colon carcinomas.
Keywords:
Colon carcinomasColon polypsMismatch repair proteinsSurvivin

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