Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K
Borderline Personality Disorder01:25

Borderline Personality Disorder

1.1K
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
1.1K
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

793
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
793
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.8K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.8K
Dissociative Disorders01:27

Dissociative Disorders

1.1K
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
1.1K
Depression: Overview01:18

Depression: Overview

1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling the spectrum of sudden cardiac death: a multidisciplinary analysis from the Friuli Venezia Giulia registry.

Frontiers in cardiovascular medicine·2025
Same author

Six Surgical Stages in the Resection of Primary Left Retroperitoneal Liposarcoma: A Standardized Comprehensive Approach.

Annals of surgical oncology·2025
Same author

Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study.

Brain, behavior, & immunity - health·2025
Same author

Resection of Primary Leiomyosarcoma of the Inferior Vena Cava and Reconstruction with a Cadaveric Homograft.

Annals of surgical oncology·2025
Same author

Advanced mapping of inorganic treatments on porous carbonate stones by combined synchrotron radiation high lateral μXRPD and μXRF.

Scientific reports·2024
Same author

Sleep changes during a spontaneous manic episode: PSG assessment in a clinical context.

Psychiatry research·2023

Related Experiment Video

Updated: Apr 29, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.8K

Fronto-limbic disconnection in bipolar disorder.

D Radaelli1, G Sferrazza Papa2, B Vai2

  • 1Department of Clinical Neurosciences, Istituto Scientifico Ospedale San Raffaele, San Raffaele Turro, Via Stamira d'Ancona 20, Milan, Italy; Centro di Eccellenza Risonanza Magnetica ad Alto Campo (CERMAC), Milano, Italy.

European Psychiatry : the Journal of the Association of European Psychiatrists
|May 24, 2014
PubMed
Summary

Bipolar disorder (BD) is linked to reduced neural connectivity between the dorsolateral prefrontal cortex (DLPFC) and amygdala. This disrupted brain network may explain emotional regulation difficulties in BD patients.

Keywords:
Affective disordersBipolar disorderDepressionDynamic causal modelingNeuroimagingfMRI

More Related Videos

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

17.2K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.4K

Related Experiment Videos

Last Updated: Apr 29, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.8K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

17.2K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.4K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Bipolar disorder (BD) is a severe mental illness characterized by emotional dysregulation.
  • Core features include affective instability and mood-congruent biases in information processing.
  • Disrupted neural connectivity is hypothesized to underlie cognitive and emotional symptoms in BD.

Purpose of the Study:

  • To investigate effective neural connectivity in patients with bipolar disorder.
  • To explore the role of specific brain regions in the pathophysiology of BD.

Main Methods:

  • Employed dynamic causal modeling (DCM) for connectivity analysis.
  • Studied 52 inpatients with bipolar disorder and 40 healthy controls.
  • Utilized a face-matching task as a cognitive activation paradigm.

Main Results:

  • Patients with BD exhibited significantly reduced endogenous connectivity from the dorsolateral prefrontal cortex (DLPFC) to the amygdala (Amy).
  • No significant group differences were found in connectivity from the amygdala to the anterior cingulate cortex (ACC) or vice versa.
  • Connectivity from DLPFC to ACC did not show significant group effects.

Conclusions:

  • The DLPFC, ACC, and amygdala form a network crucial for emotion regulation.
  • Reduced DLPFC-amygdala connectivity in BD patients may underlie abnormal mood and emotion modulation.
  • These findings highlight the role of disrupted neural circuits in the emotional disturbances of bipolar disorder.