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Updated: Apr 29, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
In vitro dosimetry of agglomerates
V Hirsch1, C Kinnear, L Rodriguez-Lorenzo
1Adolphe Merkle Institute, University of Fribourg, Route de l'Ancienne Papeterie, P.O. Box 209, Marly 1723, Switzerland.
Abstract:
Agglomeration of nanoparticles in biological fluids is a pervasive phenomenon that leads to difficulty in the interpretation of results from in vitro exposure, primarily due to differing particokinetics of agglomerates to nanoparticles. Therefore, well-defined small agglomerates were designed that possessed different particokinetic profiles, and their cellular uptake was compared to a computational model of dosimetry. The approach used here paves the way for a better understanding of the impact of agglomeration on the nanoparticle-cell interaction.

