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Impact of HLA-B*35 subtype differences on HIV disease outcome in Mexico
Claudia I Juarez-Molina1, Humberto Valenzuela-Ponce, Santiago Avila-Rios
1aDepartment of Paediatrics, University of Oxford, Oxford, UK bCentre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico. *Claudia I. Juarez-Molina and Humberto Valenzuela-Ponce contributed equally to the writing of this article.
Abstract:
HLA-B35 has consistently been associated with rapid HIV disease progression, particularly alleles of the Px group. As B35 is the most prevalent HLA-B in Mexico, we investigated HIV disease outcome in relation to HLA expression in a large cohort (n=976) of Mexicans. Contrary to the previous studies, no impact on viral load or CD4 cell count was observed in association with the B35 PY/Px groups. However, we observed differences in HIV disease outcome associated with specific HLA-B35 alleles.
