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Related Experiment Video

Updated: Apr 29, 2026

Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes

Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes

Published on: May 8, 2016

Intestinal microbiome and lymphoma development.

Mitsuko L Yamamoto¹, Robert H Schiestl

¹From the Department of Pathology, Environmental Health, Radiation Oncology, UCLA Schools of Medicine and Public Health, Los Angeles, CA.

Cancer Journal (Sudbury, Mass.)

|May 24, 2014

Summary

Animal models reveal how gut microbiota interactions can cause mucosal-associated lymphoid tissue lymphoma. Further research into this gut-immune axis may improve lymphoma treatment.

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Area of Science:

Microbiology
Immunology
Oncology

Background:

The gut immune system and intestinal microbiota must coexist, balancing tolerance and activation.
The gut microbiota comprises trillions of microbes, some essential for human health.
Dysbiosis and specific bacteria are linked to lymphomas, like mucosal-associated lymphoid tissue (MALT) lymphoma.

Purpose of the Study:

To review the application of animal models in understanding microbiota-induced lymphoma.
To elucidate the mechanisms by which gut microbes contribute to lymphoma development.
To highlight the potential of targeting the microbiota-gut axis for lymphoma therapy.

Main Methods:

Review of studies utilizing animal models to investigate gut microbiota and lymphoma.
Analysis of mechanisms linking specific bacteria to MALT lymphoma.
Examination of host-microbe interactions in the gut immune system.

Main Results:

Animal models have been crucial in establishing bacterial causation and mechanisms of MALT lymphoma.
Evidence suggests a significant interplay between gut microbiota composition and lymphoma development.
Specific bacterial species have been identified as potential triggers for MALT lymphoma.

Conclusions:

The gut microbiota plays a demonstrable role in the pathogenesis of certain lymphomas.
Animal models provide valuable insights into microbiota-driven lymphoma.
Targeting the gut microbiota holds promise for future lymphoma treatment strategies.