Related Experiment Video
Updated: Apr 29, 2026
Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
Published on: November 6, 2019
A case of cutaneous sterile pyogranuloma/granuloma syndrome in a maltese
Shinpei Kawarai1, Shinobu Matsuura, Saburo Yamamoto
1Veterinary Teaching Hospital Laboratory of Small Animal Clinics (S.K., N.K., H.M.), Department of Veterinary Medicine Laboratory of Veterinary Pathology (K.S.), and Laboratory of Microbiology I (A.K.), Azabu University, Sagamihara, Kanagawa, Japan; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (S.M.); and Central Laboratory, Japan BCG Laboratory, Kiyose, Tokyo, Japan (S.Y.).
Abstract:
Cutaneous sterile pyogranuloma/granuloma syndrome (SPGS) is a locally restricted multinodular dermatitis. Affected dogs are typically healthy, but a few show systemic signs. Herein, a case of a dog presenting with generalized ulcerative dermatitis with systemic signs of mild anemia and an increased C-reactive protein level is described. Cutaneous SPGS was diagnosed by histopathology, negative staining causative organisms, and polymerase chain reaction for Mycobacterium spp. Successful treatment was achieved by immunosuppressive drugs, including prednisolone and azathioprine, administered for at least 20 mo. Recurrences of skin lesions were observed when prednisolone and/or azathioprine were discontinued. Long-term management with immunosuppressive agents may be required if the affected dog exhibits severe symptoms of cutaneous SPGS.
