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Related Experiment Video

Updated: Apr 29, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Rapid Hebbian axonal remodeling mediated by visual stimulation.

Martin Munz¹, Delphine Gobert¹, Anne Schohl¹

¹Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 Rue University, Montreal, QC H3A 2B4, Canada.

Science (New York, N.Y.)

|May 24, 2014

Summary

Synchronous neural activity stabilizes retinal ganglion cell (RGC) axon branches in the optic tectum. Asynchronous activity promotes RGC axon growth and branching, suggesting firing patterns guide neural circuit development.

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Area of Science:

Neuroscience
Developmental Biology
Axon Guidance

Background:

Axon remodeling is crucial for establishing functional neural circuits.
The role of correlated neural activity in guiding axon development remains incompletely understood.

Purpose of the Study:

To investigate how correlated firing patterns of retinal ganglion cells (RGCs) influence their axon remodeling in the optic tectum.
To elucidate the mechanisms by which synchronous versus asynchronous neural activity shapes axonal arborization.

Main Methods:

In vivo time-lapse imaging of individual RGC axons in Xenopus laevis.
Electrophysiological analysis of RGCs stimulated synchronously or asynchronously.
Pharmacological manipulation including neurotransmitter release inhibition and N-methyl-D-aspartate receptor (NMDAR) blockade.

Main Results:

Asynchronously activated RGCs showed reduced postsynaptic drive and increased axonal branching and growth.
Synchronously activated RGCs exhibited fewer, but more stable, axonal branches.
Inhibition of neurotransmitter release or NMDAR blockade prevented the stabilizing effects of synchronous activation.

Conclusions:

Correlated neural activity, specifically synchronous firing, plays a key role in stabilizing RGC axon branches.
Synaptic NMDAR activation is implicated in mediating the effects of synchronous activity on axon stability and branch suppression.