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Updated: Apr 29, 2026

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
Published on: February 2, 2024
Developing risk prediction models for kidney injury and assessing incremental value for novel biomarkers
Kathleen F Kerr1, Allison Meisner1, Heather Thiessen-Philbrook2
1Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington;
Abstract:
The field of nephrology is actively involved in developing biomarkers and improving models for predicting patients' risks of AKI and CKD and their outcomes. However, some important aspects of evaluating biomarkers and risk models are not widely appreciated, and statistical methods are still evolving. This review describes some of the most important statistical concepts for this area of research and identifies common pitfalls. Particular attention is paid to metrics proposed within the last 5 years for quantifying the incremental predictive value of a new biomarker.
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