Related Experiment Video
Updated: Apr 29, 2026
10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
14.2K
Diffuse infiltrative primary cardiac lymphoma with delayed extracardiac involvement.
Yong Jeoung1, Se Ryeon Lee1, Ho Kim1
1Department of Internal Medicine, Korea University Medical Center, Seoul, Korea.
Chonnam Medical Journal
|May 24, 2014
Summary
Primary cardiac lymphoma (PCL), a rare heart cancer, poses diagnostic challenges. This case highlights a delayed diagnosis of diffuse large B cell lymphoma (DLBCL) involving the heart, emphasizing the need for thorough investigation.
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- Primary cardiac lymphoma (PCL) is exceptionally rare, often fatal, and difficult to diagnose due to its location and infiltrative nature.
- The prognosis for PCL is generally poor, compounded by challenges in early and accurate diagnosis.
Observation:
- A 48-year-old male presented with pericardial effusion and diffuse cardiac wall thickening, initially suspected as infiltrative heart disease.
- Initial biopsies were inconclusive, delaying definitive diagnosis for 20 months.
Findings:
- The patient was ultimately diagnosed with primary cardiac diffuse large B cell lymphoma (DLBCL) via a cervical lymph node biopsy.
- Chemotherapy led to significant improvement in DLBCL lesions, including cardiac wall thickening.
Implications:
- This case underscores the diagnostic complexities of infiltrative primary cardiac lymphoma (PCL).
- The findings suggest PCL can present with delayed extracardiac involvement, necessitating comprehensive evaluation.
- Successful treatment with chemotherapy indicates its potential efficacy in managing cardiac lymphoma.
Related Concept Videos
01:30Cardiomyopathy II: Dilated Cardiomyopathy
788
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
788
01:16Primary Lymphoid Organs
9.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
9.6K
01:31Pulmonary Tuberculosis III
1.7K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.7K
01:15Secondary Lymphoid Organs
7.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
7.2K
01:27Myocarditis II: Clinical Features and Diagnostic Tests
493
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
493
01:25Cardiomyopathy I: Introduction and Classification
817
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
817