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Diffuse infiltrative primary cardiac lymphoma with delayed extracardiac involvement

Yong Jeoung1, Se Ryeon Lee1, Ho Kim1

  • 1Department of Internal Medicine, Korea University Medical Center, Seoul, Korea.

Chonnam Medical Journal
|May 24, 2014
PubMed

Insights

Primary cardiac lymphoma (PCL), a rare heart cancer, poses diagnostic challenges. This case highlights a delayed diagnosis of diffuse large B cell lymphoma (DLBCL) involving the heart, emphasizing the need for thorough investigation.

Area of Science:

  • Cardiology
  • Oncology
  • Pathology

Background:

  • Primary cardiac lymphoma (PCL) is exceptionally rare, often fatal, and difficult to diagnose due to its location and infiltrative nature.
  • The prognosis for PCL is generally poor, compounded by challenges in early and accurate diagnosis.

Observation:

  • A 48-year-old male presented with pericardial effusion and diffuse cardiac wall thickening, initially suspected as infiltrative heart disease.
  • Initial biopsies were inconclusive, delaying definitive diagnosis for 20 months.

Findings:

  • The patient was ultimately diagnosed with primary cardiac diffuse large B cell lymphoma (DLBCL) via a cervical lymph node biopsy.
  • Chemotherapy led to significant improvement in DLBCL lesions, including cardiac wall thickening.

Implications:

  • This case underscores the diagnostic complexities of infiltrative primary cardiac lymphoma (PCL).
  • The findings suggest PCL can present with delayed extracardiac involvement, necessitating comprehensive evaluation.
  • Successful treatment with chemotherapy indicates its potential efficacy in managing cardiac lymphoma.

Keywords:
DiagnosisHeartLymphoma

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