Related Experiment Video
Updated: Apr 29, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
Mechanisms and functions of inflammasomes
Mohamed Lamkanfi1, Vishva M Dixit2
1Department of Medical Protein Research, VIB, Ghent 9000, Belgium; Department of Biochemistry, Ghent University, Ghent 9000, Belgium.
Abstract:
Recent studies have offered a glimpse into the sophisticated mechanisms by which inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18. Activation of caspases 1 and 11 in canonical and noncanonical inflammasomes, respectively, also protects against infection by triggering pyroptosis, a proinflammatory and lytic mode of cell death. The therapeutic potential of inhibiting these proinflammatory caspases in infectious and autoimmune diseases is raised by the successful deployment of anti-IL-1 therapies to control autoinflammatory diseases associated with aberrant inflammasome signaling. This Review summarizes recent insights into inflammasome biology and discusses the questions that remain in the field.
Related Concept Videos
Caspases
Inflammation
Inflammation: Introduction
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
The Extrinsic Apoptotic Pathway
Acute Inflammation I: Inflammatory Response

