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Updated: Apr 29, 2026

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Published on: September 4, 2017

Brainstem melanomas presenting as a cavernous malformation.

A Y Lu¹, A R Patel², G A Kuzmik¹

¹Department of Neurosurgery, Yale School of Medicine, New Haven CT 06510, United States.

Neuro-Chirurgie

|May 27, 2014

Summary

This summary is machine-generated.

Brainstem melanoma can mimic cavernous malformations, presenting as hemorrhages. Despite treatment, metastatic brainstem melanoma has an aggressive course and poor prognosis.

Keywords:

Brain stem Cavernous malformations of CNS and retina Malformations caverneuses du système nerveux central et de la rétine Melanoma Mélanome Tronc cérébral

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Last Updated: Apr 29, 2026

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Area of Science:

Neuro-oncology
Neurosurgery
Neuropathology

Background:

Brainstem melanoma is challenging to differentiate from cavernous malformations radiographically and clinically.
Treatment and prognosis differ significantly between these two conditions.

Observation:

Two cases of brainstem melanoma presenting as hemorrhages are detailed.
A 69-year-old male with a midbrain lesion experienced rebleeding and death. A 62-year-old female with a pontine hemorrhage underwent resection and radiation therapy, also with a fatal outcome.

Findings:

Histopathology confirmed melanoma in both resected brainstem lesions.
Both patients experienced aggressive disease progression and ultimately succumbed to their condition.

Implications:

Brainstem melanoma can mimic other vascular lesions, necessitating careful diagnosis.
While treatments like radiosurgery, radiation, and resection exist, metastatic brainstem melanoma carries a poor prognosis.