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Updated: Apr 29, 2026

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
Published on: April 1, 2022
Nitric oxide and histone acetylation-shaping craniofacial development
Libera Berghella1, Pier Lorenzo Puri2
1Epigenetics & Regenerative Medicine, IRCCS Fondazione Santa Lucia, 00142 Rome, Italy.
Abstract:
Previous work linked nitric oxide (NO) signaling to histone deacetelyases (HDACs) in the control of tissue homeostasis and suggested that deregulation of this signaling contributes to human diseases. In the previous issue of Chemistry & Biology, Kong and colleagues showed that coordinated NO signaling and histone acetylation are required for proper cranial neural crest development and craniofacial morphogenesis and suggested that alterations of NO/acetylation network can contribute to the pathogenesis of craniofacial malformations.
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