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Published on: June 8, 2017
Targeting the olfactory bulb during experimental cerebral malaria
Laurent Rénia1, Shanshan Wu Howland1
1Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis, 138648 Singapore.
Abstract:
Malaria is responsible for over 500 million clinical cases and over 500000 deaths annually. Fatalities arise from a range of overlapping syndromes, such as cerebral malaria, whose pathogenesis is still incompletely understood. In a new study, Coban and colleagues provide new clues on the involvement of the olfactory bulb during experimental cerebral malaria in mice that open the way to testable hypotheses and potentially earlier intervention in humans.
Insights
Researchers found the olfactory bulb plays a role in experimental cerebral malaria in mice. This discovery may lead to earlier diagnosis and intervention for severe malaria in humans.
Area of Science:
- Neuroscience
- Infectious Diseases
- Immunology
Background:
- Malaria causes over 500 million cases and 500,000 deaths yearly.
- Cerebral malaria is a severe complication with poorly understood pathogenesis.
- Early detection and intervention strategies for severe malaria are crucial.
Purpose of the Study:
- To investigate the role of the olfactory bulb in experimental cerebral malaria.
- To identify potential new targets for understanding and treating severe malaria.
Main Methods:
- Utilized a mouse model of experimental cerebral malaria.
- Examined the involvement of the olfactory bulb during the disease progression.
Main Results:
- New evidence suggests the olfactory bulb is involved in experimental cerebral malaria.
- Findings provide insights into the complex pathogenesis of cerebral malaria.
Conclusions:
- The olfactory bulb's role in cerebral malaria opens new avenues for research.
- This study may pave the way for earlier diagnostic and therapeutic interventions in human malaria.
