Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dual-targeting macrophage membrane nanosystem enhances radiotherapy-induced antitumor immunity <i>via</i> synergistic nuclear and mitochondrial DNA damage.

Biomaterials science·2026

Same author

A <sup>19</sup>F MRI/NIR-FL Nanoprobe for "Turn-On" Imaging of β-Secretase (BACE1) Activity in Alzheimer's Disease.

Angewandte Chemie (International ed. in English)·2026

Same author

Ionomycin enhances radiosensitivity in breast cancer through reactive oxygen species generation and mitochondrial permeability transition pore opening.

Medical gas research·2026

Same author

Calcium overload induces reactive oxygen species to enhance glioblastoma radiosensitivity.

Medical gas research·2026

Same author

Localized and sustained release of Botulinum Toxin A from supramolecular peptide hydrogel for strabismus treatment.

Theranostics·2026

Same author

FGFR2-responsive self-assembled hydrogel releases its inhibitor to suppress the progression of endometriosis.

Journal of controlled release : official journal of the Controlled Release Society·2026

Search research articles

Related Experiment Video

Updated: Apr 29, 2026

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Using magnetic resonance imaging to study enzymatic hydrogelation.

Weijuan Wang¹, Junchao Qian, Anming Tang

¹CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China , Hefei, Anhui 230026, China.

Analytical Chemistry

|May 27, 2014

Summary

This study introduces magnetic resonance imaging (MRI) to investigate enzymatic hydrogelation, revealing how nanofiber network density impacts encapsulated water molecule behavior in hydrogels.

More Related Videos

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

Related Experiment Videos

Last Updated: Apr 29, 2026

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

Area of Science:

Biomaterials Science
Supramolecular Chemistry
Biophysics

Background:

Supramolecular hydrogels are vital biomaterials, but the behavior of encapsulated water remains poorly understood.
Enzymatic hydrogelation offers a controlled method for hydrogel formation.
Understanding water dynamics is crucial for hydrogel applications.

Purpose of the Study:

To explore magnetic resonance imaging (MRI) methods for studying enzymatic hydrogelation.
To investigate the relationship between hydrogel network density and water molecule behavior.
To establish a novel in vitro method for studying fibrous aggregate diseases.

Main Methods:

Designed a precursor molecule that self-assembles into nanofibers and forms hydrogel I (gel I) via phosphatase catalysis.
Systematically analyzed mechanical properties, pore size, water diffusion rates, and magnetic resonance relaxation times (T1 and T2) of gel I at varying precursor concentrations.
Acquired diffusion-weighted (1)H MR images at 9.4 T for gel I phantoms.

Main Results:

MRI data revealed how nanofiber network density influences water proton relaxation behaviors within the hydrogel.
Rheological analyses and cryo-transmission electron microscopy (cryo-TEM) showed increased gel elasticity and decreased pore size with higher precursor concentrations.
Increased network density led to faster proton relaxation rates (shortened T1, T2) and a decreased apparent diffusion coefficient (ADC) for encapsulated water.

Conclusions:

MRI provides a powerful tool to study enzymatic hydrogelation and water dynamics in hydrogels.
Hydrogel network density significantly affects the physical properties and water diffusion characteristics.
This MRI approach offers a new in vitro model for studying diseases associated with fibrous aggregates.